Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loteprednol Etabonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 14/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | IL6 | P05231 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | GLUL | P15104 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loteprednol Etabonate SCHEMBL3822250 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL12738239 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL12045348 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL669340 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL15325052 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL23765700 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL3413440 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL13379816 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL22078123 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 | |
| Loteprednol Etabonate SCHEMBL506024 | 1.00 | NR3C1 (1.00) | NR3C1PGRABCB11NR1I2ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12577 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075220-A | Contact lens for treating xerophthalmia and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026097978-A1 | LIGNIN-MODIFIED WATERBORNE POLYURETHANE STRIPPABLE COATING AND PREPARATION METHOD THEREFOR | 中海油常州涂料化工研究院有限公司 | 2026-05-15 | — | — | WO | claimed |
| CN-116321550-B | Electrothermal slurry and preparation method thereof | 广东骏丰频谱股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122037703-A | Particle sound absorption board maintenance material and preparation method and construction method thereof | 中建西部建设建材科学研究院有限公司 | 2026-05-15 | — | — | CN | claimed |
| EP-4724839-A2 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | Mediprint Ophthalmics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | MEDIPRINT OPHTHALMICS INC. (US) | 2026-04-02 | — | — | US | claimed |
| US-20260091018-A1 | COMBINATION PREPARATION CONTAINING HETEROCYCLIDENE ACETAMIDE DERIVATIVE | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2026-04-02 | — | — | US | claimed |
| US-12589069-B2 | Ophthalmic suspension composition | BAUSCH + LOMB IRELAND LIMITED (IE) | 2026-03-31 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4259102-B1 | COMPOSITIONS AND METHODS FOR MUCOSAL DRUG DELIVERY | UNIV CALIFORNIA (US) | 2026-03-11 | — | — | EP | claimed |
| EP-0730443-A4 | SUSPENSION OF LOTEPREDNOL ETABONATE | PHARMOS CORP (US) | 1997-11-05 | — | — | EP | claimed |
| EP-0794783-A1 | CYCLODEXTRINS AS SUSPENDING AGENTS FOR PHARMACEUTICAL SUSPENSIONS | PHARMOS CORPORATION (US) | 1997-09-17 | — | — | EP | claimed |
| US-5576311-A | DRUG SUSPENSION IN WATER | PHARMOS CORPORATION (US) | 1996-11-19 | — | — | US | claimed |
| EP-0730443-A1 | SUSPENSION OF LOTEPREDNOL ETABONATE | PHARMOS CORPORATION (US) | 1996-09-11 | — | — | EP | claimed |
| US-5540930-A | NONAGGLOMERATING SUSPENSION | PHARMOS CORPORATION (US) | 1996-07-30 | — | — | US | claimed |
| WO-1996016659-A1 | CYCLODEXTRINS AS SUSPENDING AGENTS FOR PHARMACEUTICAL SUSPENSIONS | PHARMOS CORP. (US) | 1996-06-06 | — | — | WO | claimed |
| EP-0709099-A2 | An aqueous nasal suspension comprising cyclodextrin | Senju Pharmaceutical Co., Ltd. (JP) | 1996-05-01 | — | — | EP | claimed |
| WO-1995011669-A1 | SUSPENSION OF LOTEPREDNOL ETABONATE | PHARMOS CORPORATION (US) | 1995-05-04 | — | — | WO | claimed |
| US-4996335-A | Soft steroids having anti-inflammatory activity | Bodor, Nicholas S. (US) | 1991-02-26 | — | — | US | claimed |
| EP-0137212-A2 | Ointment bases and ointments | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-04-17 | — | — | EP | claimed |