Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21017395 | 0.82 | ALDH1A1 (0.37) | PLK1LYNSRCBTKNUDT1 | |
| SCHEMBL26551523 | 0.77 | TLR8 (0.44) | LYNSRCBTKTLR8NUDT1 | |
| SCHEMBL1154553 | 0.74 | CYP1A2 (0.51) | LYNSRCBTKMEN1NPC1 | |
| SCHEMBL28136437 | 0.73 | MALT1 (0.51) | PLK1MAP4K1CCNE2CDK4CCND1 | |
| SCHEMBL21017097 | 0.73 | PLK1 (0.38) | PLK1TLR8NUDT1HRH3LATS1 | |
| SCHEMBL27147919 | 0.73 | CYP1A2 (0.56) | TLR8NUDT1ALDH1A1HRH3CLK4 | |
| SCHEMBL28158326 | 0.73 | MEN1 (0.44) | PLK1TLR8NUDT1MEN1NPC1 | |
| SCHEMBL16244502 | 0.73 | ROCK1 (0.40) | LYNSRCBTKTLR8NUDT1 | |
| SCHEMBL19150881 | 0.71 | ADORA3 (0.46) | MAPK8NPC1RAB9AKMT2A | |
| SCHEMBL19116517 | 0.71 | ADORA1 (0.44) | LYNSRCBTKMAPK8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253554-A1 | SULFONE PYRIDINE ALKYL AMIDE-SUBSTITUTED HETEROARYL COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253554-A1 | SULFONE PYRIDINE ALKYL AMIDE-SUBSTITUTED HETEROARYL COMPOUNDS | TYK2, JAK3, JAK2 | PLK1 1635/4885LYN 151/4885SRC 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.