Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.31 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843089 | 1.00 | BTK (0.40) | BTKKLKB1L3MBTL1HSD17B10HPGDS | |
| SCHEMBL23769151 | 0.86 | KLKB1 (0.40) | BTKKLKB1 | |
| SCHEMBL23769333 | 0.85 | BTK (0.43) | BTKKLKB1L3MBTL1HSD17B10HPGDS | |
| SCHEMBL23768871 | 0.82 | CA5A (0.35) | KLKB1 | |
| SCHEMBL23769219 | 0.81 | L3MBTL1 (0.40) | BTKKLKB1L3MBTL1HSD17B10HPGDS | |
| SCHEMBL23754313 | 0.81 | KLKB1 (0.42) | BTKKLKB1L3MBTL1HSD17B10POLB | |
| SCHEMBL23843223 | 0.81 | KLKB1 (0.42) | BTKKLKB1L3MBTL1HSD17B10POLB | |
| SCHEMBL23754309 | 0.80 | KLKB1 (0.45) | BTKKLKB1L3MBTL1HSD17B10POLB | |
| SCHEMBL23754184 | 0.80 | KLKB1 (0.42) | BTKKLKB1L3MBTL1HSD17B10HPGDS | |
| SCHEMBL29906534 | 0.80 | KLKB1 (0.42) | BTKKLKB1L3MBTL1HSD17B10HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |