Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 7/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23754326 | 1.00 | RBP4 (0.42) | RBP4HCRTR1HCRTR2PDE10ASMO | |
| SCHEMBL30087453 | 1.00 | RBP4 (0.42) | RBP4HCRTR1HCRTR2PDE10ASMO | |
| SCHEMBL29906550 | 0.76 | PIM1 (0.36) | RBP4HCRTR1HCRTR2PDE10APIM1 | |
| SCHEMBL23768893 | 0.76 | PIM1 (0.36) | RBP4HCRTR1HCRTR2PDE10APIM1 | |
| SCHEMBL23754012 | 0.72 | TUBB4A (0.46) | — | |
| SCHEMBL23753973 | 0.70 | MAPT (0.45) | RBP4HCRTR1HCRTR2 | |
| SCHEMBL29906597 | 0.69 | HCRTR1 (0.43) | RBP4HCRTR1HCRTR2 | |
| SCHEMBL23753993 | 0.69 | HCRTR1 (0.43) | RBP4HCRTR1HCRTR2 | |
| SCHEMBL23769643 | 0.69 | BTK (0.48) | RBP4 | |
| SCHEMBL23768854 | 0.69 | KLKB1 (0.43) | RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |