Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23830178 | 0.89 | KLKB1 (0.39) | NOTUMKLKB1BTK | |
| SCHEMBL23769531 | 0.86 | NOTUM (0.43) | NOTUMKLKB1KDM4EMAPTKCNMA1 | |
| SCHEMBL23769239 | 0.84 | KLKB1 (0.40) | NOTUMKLKB1BTKDPP4 | |
| SCHEMBL23773107 | 0.84 | KLKB1 (0.44) | NOTUMKLKB1BTKDPP4 | |
| SCHEMBL23843182 | 0.82 | KLKB1 (0.47) | KLKB1BTKDPP4 | |
| SCHEMBL23769144 | 0.80 | SMPD3 (0.38) | KLKB1 | |
| SCHEMBL23769187 | 0.77 | ALDH1A1 (0.52) | KLKB1BTK | |
| SCHEMBL23830164 | 0.76 | KLKB1 (0.39) | KLKB1BTK | |
| SCHEMBL23830230 | 0.76 | BTK (0.41) | KLKB1BTK | |
| SCHEMBL23830171 | 0.75 | KLKB1 (0.39) | KLKB1BTKKCNMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |