Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 10/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 5/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23830164 | 0.92 | KLKB1 (0.39) | KLKB1BTK | |
| SCHEMBL23769617 | 0.84 | NOTUM (0.46) | KLKB1NOTUMBTKDPP4 | |
| SCHEMBL23843156 | 0.83 | KLKB1 (0.47) | KLKB1BTK | |
| SCHEMBL23773107 | 0.82 | KLKB1 (0.44) | KLKB1NOTUMBTKDPP4 | |
| SCHEMBL23830230 | 0.81 | BTK (0.41) | KLKB1BTK | |
| SCHEMBL23769616 | 0.81 | SMPD3 (0.36) | KLKB1 | |
| SCHEMBL23830178 | 0.80 | KLKB1 (0.39) | KLKB1NOTUMBTK | |
| SCHEMBL23830171 | 0.80 | KLKB1 (0.39) | KLKB1BTK | |
| SCHEMBL23830237 | 0.78 | KLKB1 (0.40) | KLKB1BTK | |
| SCHEMBL30087403 | 0.77 | ALDH1A1 (0.48) | KLKB1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |