Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 12/20 | 0.41 |
| ▸ | CA1 | P00915 | 12/20 | 0.41 |
| ▸ | CA2 | P00918 | 12/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL26257 | 0.95 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL1276519 | 0.94 | ALDH1A1 (0.60) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL9517821 | 0.94 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL345215 | 0.94 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7102453 | 0.94 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL6546528 | 0.94 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL7217920 | 0.94 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL23860715 | 0.93 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL386952 | 0.93 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1NR1I2ABCB11 | |
| Benzthiazide SCHEMBL386685 | 0.93 | ALDH1A1 (0.58) | ALDH1A1KDM4EMEN1NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230032826-A1 | PRODUCTION OF RECOMBINANT VIRAL VECTORS FROM PLANT HAIRY ROOTS | GENETHON (FR) | 2023-02-02 | — | — | US | disclosed |
| US-11414653-B2 | Promoter useful for high expression of a heterologous gene of interest in Aspergillus niger | NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (US) | 2022-08-16 | — | — | US | disclosed |
| WO-2021123122-A1 | PRODUCTION OF RECOMBINANT VIRAL VECTORS FROM PLANT HAIRY ROOTS | GENETHON (FR) | 2021-06-24 | — | — | WO | disclosed |
| US-20190169584-A1 | Promoter useful for high expression of a heterologous gene of interest in Aspergillus niger | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-06-06 | — | — | US | disclosed |
| US-9926539-B2 | Cytochrome P450 enzymes from sorghum bicolor | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160137988-A1 | NOVEL CYTOCHROME P450 ENZYMES FROM SORGHUM BICOLOR | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE | 2016-05-19 | — | — | US | disclosed |
| US-9284537-B2 | Cytochrome P450 enzymes from Sorghum bicolor | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2016-03-15 | — | — | US | disclosed |
| US-20140308731-A1 | Novel Cytochrome P450 Enzymes From Sorghum Bicolor | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE | 2014-10-16 | — | — | US | disclosed |
| CN-101056889-B | Transcription factors fungi regulon zinc binuclear cluster family | DANISCO | 2013-12-04 | — | — | CN | disclosed |
| WO-2013078520-A2 | METHOD FOR PRODUCING GENETICALLY MODIFIED PLANTS CAPABLE OF CONTROLLING THE PRODUCTION OF ETHYLENE HORMONE, THUS OBTAINED GENETICALLY MODIFIED PLANTS, RECOMBINANT DNA VECTOR AND USES THEREOF | UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP (BR) | 2013-06-06 | — | — | WO | disclosed |
| US-8017341-B2 | Transcription factors | DANISCO A/S (DK) | 2011-09-13 | — | — | US | disclosed |
| EP-2210899-A1 | pntr transcription factor | Danisco A/S (DK) | 2010-07-28 | — | — | EP | disclosed |
| EP-1809659-B1 | PNTR TRANSCRIPTION FACTOR KNOCK-OUT AND USES THEREOF | DANISCO (DK) | 2010-03-31 | — | — | EP | disclosed |
| US-20070254336-A1 | Transcription Factors | INTERNATIONAL N&H DENMARK APS (DK) | 2007-11-01 | — | — | US | disclosed |
| CN-101056889-A | Transcription factors fungi regulon zinc binuclear cluster family | DANISCO NIKOLAEV IGOR MADRID S (DK) | 2007-10-17 | — | — | CN | disclosed |
| EP-1809659-A2 | TRANSCRIPTION FACTORS | DANISCO A/S (DK) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006051418-A2 | TRANSCRIPTION FACTOR OF THE ZN BINUCLEAR CLUSTER FAMILY OF FUNGAL REGULATORS | DANISCO A/S (DK) | 2006-05-18 | — | — | WO | disclosed |
| US-6326477-B1 | NUCLEOTIDE SEQUENCES CODING POLYPEPTIDE WHICH MAINTAINS VIABILITY IN GENETICALLY ENGINEEERED FUNGUS; FOR USE AS A TOOL IN CONTROLLED GENE EXPRESSION | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 2001-12-04 | — | — | US | disclosed |
| EP-0862639-A1 | PROCESS FOR MODIFYING GLUCOSE REPRESSION | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997009438-A1 | PROCESS FOR MODIFYING GLUCOSE REPRESSION | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 1997-03-13 | — | — | WO | disclosed |