Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 12/20 | 0.41 |
| ▸ | CA2 | P00918 | 11/20 | 0.41 |
| ▸ | CA12 | O43570 | 10/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzthiazide SCHEMBL26257 | 0.99 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7217920 | 0.98 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL7102453 | 0.98 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL6546528 | 0.98 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL9517821 | 0.98 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL1276519 | 0.96 | ALDH1A1 (0.60) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL23860715 | 0.94 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL386952 | 0.94 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL386685 | 0.94 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 | |
| Benzthiazide SCHEMBL2376967 | 0.94 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306304-B2 | Mutations in iron-sulfur cluster proteins that improve xylose utilization | LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU) | 2022-04-19 | — | — | US | disclosed |
| US-20200115697-A1 | MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION | DANSTAR FERMENT AG (CH) | 2020-04-16 | — | — | US | disclosed |
| US-10465181-B2 | Mutations in iron-sulfur cluster proteins that improve xylose utilization | LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU) | 2019-11-05 | — | — | US | disclosed |
| US-10308964-B2 | Activity of Fe—S cluster requiring proteins | BUTAMAX ADVANCED BIOFUELS LLC (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180251750-A1 | MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION | DANSTAR FERMENT AG (CH) | 2018-09-06 | — | — | US | disclosed |
| EP-2536821-B1 | IMPROVING ACTIVITY OF FE-S CLUSTER REQUIRING PROTEINS | BUTAMAX TM ADVANCED BIOFUELS (US) | 2018-06-13 | — | — | EP | disclosed |
| US-9920312-B2 | Mutations in iron-sulfur cluster proteins that improve xylose utilization | LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU) | 2018-03-20 | — | — | US | disclosed |
| EP-3180419-A1 | MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION | Lallemand Hungary Liquidity Management LLC (HU) | 2017-06-21 | — | — | EP | disclosed |
| US-20170101653-A1 | Activity of Fe-S Cluster Requiring Proteins | GEVO, INC. | 2017-04-13 | — | — | US | disclosed |
| US-9611482-B2 | Activity of Fe-S cluster requiring proteins | BUTAMAX ADVANCED BIOFUELS LLC (US) | 2017-04-04 | — | — | US | disclosed |
| EP-0830456-B1 | ISOLATED FrpB NUCLEIC ACID MOLECULE AND VACCINE | UNIV NORTH CAROLINA (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050271681-A1 | Isolated FrpB nucleic acid molecule and vaccine | SPARLING P F | 2005-12-08 | — | — | US | disclosed |
| WO-2005091733-A2 | TRAITS IN RECOMBINANT XYLOSE-GROWING SACCHAROMYCES CEREVISIAE STRAINS USING GENOME-WIDE TRANSCRIPTION ANALYSIS | FORSKARPATENT I SYD AB (SE) | 2005-10-06 | — | — | WO | disclosed |
| US-20050209305-A1 | Methods for the production of biliverdin | PENDRAK MICHAEL L | 2005-09-22 | — | — | US | disclosed |
| US-20030096368-A1 | Isolated FrpB nucleic acid molecule and vaccine | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2003-05-22 | — | — | US | disclosed |
| US-6265567-B1 | NUCLEOTIDE SEQUENCES CODING EXTERIOR MEMBRANE POLYPEPTIDES; FOR THE DEVELOPMENT OF VACCINES WHICH PREVENT INFECTION BY PREFERENTIAL MICROORGANISMS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-07-24 | — | — | US | disclosed |
| EP-0830456-A4 | ISOLATED FrpB NUCLEIC ACID MOLECULE AND VACCINE | UNIV NORTH CAROLINA (US) | 2001-03-14 | — | — | EP | disclosed |
| EP-0830456-A1 | ISOLATED FrpB NUCLEIC ACID MOLECULE AND VACCINE | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ; Office of Research Services (US) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996031618-A9 | ISOLATED FrpB NUCLEIC ACID MOLECULE AND VACCINE | — | 1996-12-05 | — | — | WO | disclosed |
| WO-1996031618-A1 | ISOLATED FrpB NUCLEIC ACID MOLECULE AND VACCINE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-10-10 | — | — | WO | disclosed |