Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770756 | 0.90 | BACE1 (0.36) | MPLPTPN1HSD11B1CRHR1BACE1 | |
| SCHEMBL23770614 | 0.86 | PTPN1 (0.30) | PTPN1 | |
| SCHEMBL23770693 | 0.86 | PTPN1 (0.30) | MPLPTPN1 | |
| SCHEMBL23770680 | 0.86 | CTSA (0.31) | — | |
| SCHEMBL23770549 | 0.84 | ABL1 (0.32) | MPL | |
| SCHEMBL23770590 | 0.83 | ADORA2A (0.35) | BACE1 | |
| SCHEMBL23770752 | 0.82 | MPL (0.34) | MPLPTPN1HSD11B1 | |
| SCHEMBL23770605 | 0.82 | — | — | |
| SCHEMBL23770569 | 0.82 | EPAS1 (0.34) | MPLHSD11B1BACE1 | |
| SCHEMBL23770409 | 0.81 | BACE1 (0.35) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |