Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 7/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770693 | 0.91 | PTPN1 (0.30) | MPL | |
| SCHEMBL23770756 | 0.87 | BACE1 (0.36) | SCN9AMPL | |
| SCHEMBL23770419 | 0.85 | GAA (0.32) | — | |
| SCHEMBL23770542 | 0.84 | MPL (0.34) | MPL | |
| SCHEMBL23770550 | 0.84 | NOS3 (0.31) | — | |
| SCHEMBL23770432 | 0.82 | SCN9A (0.30) | SCN9A | |
| SCHEMBL23770569 | 0.82 | EPAS1 (0.34) | MPL | |
| SCHEMBL23770602 | 0.81 | NOS3 (0.33) | SCN9A | |
| SCHEMBL23770626 | 0.81 | TRPV1 (0.35) | SCN5ASCN9A | |
| SCHEMBL23770434 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |