Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970083 | 1.00 | BTK (0.34) | BTKRORCEIF2AK4DGAT1KCNH2 | |
| SCHEMBL23770654 | 0.91 | RORC (0.40) | BTKRORCMEN1KMT2AKRAS | |
| SCHEMBL19970208 | 0.90 | BTK (0.34) | BTKEIF2AK4EPHX2KIF18A | |
| SCHEMBL19970137 | 0.90 | BTK (0.34) | BTKEIF2AK4EPHX2KIF18A | |
| SCHEMBL19970081 | 0.90 | BTK (0.33) | BTKEIF2AK4EPHX2 | |
| SCHEMBL19970020 | 0.90 | RBP4 (0.35) | BTKEIF2AK4 | |
| SCHEMBL19970129 | 0.90 | RBP4 (0.35) | BTKEIF2AK4 | |
| SCHEMBL23770792 | 0.90 | EPHX2 (0.34) | BTKRORCEIF2AK4EPHX2KIF18A | |
| SCHEMBL19970127 | 0.90 | BTK (0.33) | BTKEIF2AK4EPHX2 | |
| SCHEMBL19970015 | 0.90 | BTK (0.33) | BTKEIF2AK4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |