Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.38 |
| ▸ | ITGAL | P20701 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770640 | 0.92 | ITGB2 (0.40) | MPLIDH2ITGB2ICAM1ITGAL | |
| SCHEMBL23770488 | 0.90 | ITGB2 (0.40) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL23770759 | 0.88 | MPL (0.43) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL23770793 | 0.86 | MPL (0.38) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL23770608 | 0.86 | NOTUM (0.41) | MPLITGB2ICAM1ITGALNOTUM | |
| SCHEMBL23770689 | 0.84 | ITGB2 (0.40) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL19970130 | 0.84 | ITGB2 (0.40) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL19970013 | 0.84 | ITGB2 (0.40) | GPBAR1MPLIDH2ITGB2ICAM1 | |
| SCHEMBL19970118 | 0.84 | RORC (0.35) | KCNH2 | |
| SCHEMBL23770635 | 0.84 | IDH2 (0.39) | MPLIDH2ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |