Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.41 |
| ▸ | MPL | P40238 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.35 |
| ▸ | ITGAL | P20701 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770488 | 0.95 | ITGB2 (0.40) | NOTUMMPLTTRITGB2ICAM1 | |
| SCHEMBL23770806 | 0.94 | RBP4 (0.36) | NOTUMMPLRORCTTRITGB2 | |
| SCHEMBL23770803 | 0.87 | EIF2AK4 (0.39) | NOTUMMPL | |
| SCHEMBL19970153 | 0.87 | EIF2AK4 (0.39) | NOTUMMPL | |
| SCHEMBL23770865 | 0.87 | KHK (0.35) | MPLRORCTTR | |
| SCHEMBL23770674 | 0.87 | MPL (0.38) | MPLTTR | |
| SCHEMBL23770759 | 0.86 | MPL (0.43) | NOTUMMPLRORCITGB2ICAM1 | |
| SCHEMBL23770658 | 0.86 | CTSS (0.31) | TTR | |
| SCHEMBL23770793 | 0.86 | MPL (0.38) | NOTUMMPLRORCITGB2ICAM1 | |
| SCHEMBL19970013 | 0.86 | ITGB2 (0.40) | NOTUMMPLTTRITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |