Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ATF4 | P18848 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23773254 | 0.92 | ATF4 (0.46) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773238 | 0.91 | ATF4 (0.45) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773242 | 0.88 | KMT2A (0.43) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773278 | 0.85 | MEN1 (0.43) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773227 | 0.84 | HPGD (0.51) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773257 | 0.81 | MEN1 (0.43) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL23773246 | 0.79 | KMT2A (0.46) | NPC1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL22669453 | 0.79 | ATF4 (0.51) | NPC1RAB9AATF4MEN1KMT2A | |
| SCHEMBL23773091 | 0.77 | LMNA (0.45) | NPC1CYP1A2HPGDCYP2C19RAB9A | |
| SCHEMBL25797240 | 0.75 | ATF4 (0.48) | ALDH1A1LMNAATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253528-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253528-A1 | CHEMICAL COMPOUNDS | ATF4, EIF2AK4, ATF1 | NPC1 62/4885CYP1A2 2248/4885CYP2C9 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.