SCHEMBL23775813 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	1/20	0.38

▸	TRPA1	O75762	1/20	0.36

▸	PTGS1	P23219	1/20	0.36

▸	CACNA1C	Q13936	1/20	0.36

▸	ALDH1A1	P00352	2/20	0.35

▸	GAA	P10253	1/20	0.35

▸	ALOX12	P18054	1/20	0.35

▸	HTT	P42858	1/20	0.35

▸	HIF1A	Q16665	1/20	0.35

▸	KIF11	P52732	1/20	0.35

▸	NPC1	O15118	2/20	0.33

▸	RAB9A	P51151	2/20	0.33

▸	SCN4A	P35499	1/20	0.33

▸	SMN1; SMN2	Q16637	1/20	0.33

▸	RNASEH1	O60930	1/20	0.33

▸	KDM4E	B2RXH2	1/20	0.33

▸	MEN1	O00255	1/20	0.33

▸	TP53	P04637	1/20	0.33

▸	MAPT	P10636	1/20	0.33

▸	KMT2A	Q03164	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14446398	0.84	MAPT (0.38)	LMNAALDH1A1GAANPC1RAB9A
SCHEMBL12856649	0.78	LMNA (0.43)	LMNATRPA1PTGS1CACNA1CALDH1A1
SCHEMBL2707237	0.78	LMNA (0.43)	LMNATRPA1PTGS1CACNA1CALDH1A1
SCHEMBL23746866	0.78	LMNA (0.43)	LMNATRPA1PTGS1CACNA1CALDH1A1
SCHEMBL11824302	0.73	NOX1 (0.33)	NOX1
SCHEMBL11823610	0.73	ABCB11 (0.38)	TRPA1PTGS1NOX1
SCHEMBL9778269	0.73	NOX1 (0.35)	NOX1
SCHEMBL11827566	0.72	ABCB11 (0.37)	TRPA1
SCHEMBL11830526	0.72	ABCB11 (0.37)	—
SCHEMBL11825872	0.72	PSEN1 (0.39)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021160132-A1	HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF	上海美悦生物科技发展有限公司	2021-08-19	—	—	WO	disclosed