Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.59 |
| ▸ | RET | P07949 | 6/20 | 0.59 |
| ▸ | CDK7 | P50613 | 6/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | FYN | P06241 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31526668 | 0.85 | CDK5 (0.44) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL31526516 | 0.80 | ABL1 (0.51) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL20468160 | 0.80 | CDK5 (0.41) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL23443031 | 0.77 | ALDH1A1 (0.50) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL12400227 | 0.77 | ABL1 (0.51) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL27882743 | 0.77 | ABL1 (0.51) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL17090692 | 0.74 | ADORA2A (0.38) | CDK5BRD4SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL13072745 | 0.72 | ADORA2A (0.37) | CDK5BRD4SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL2038921 | 0.71 | BRD4 (0.47) | ABL1RETCDK7CDK5PRKAA1 | |
| SCHEMBL15021897 | 0.70 | CDK5 (0.73) | ABL1RETCDK7CDK5PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102232076-A | Pyrrolopyrazinyl urea kinase inhibitors | HOFFMANN LA ROCHE | 2011-11-02 | — | — | CN | disclosed |
| EP-2373653-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| US-8012974-B2 | Pyrrolopyrazinyl urea kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-09-06 | — | — | US | disclosed |
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | ROCHE PALO ALTO LLC | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | JAK1, JAK3, ULK3 | ABL1 273/4885RET 271/4885CDK7 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.