Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23778031 | 0.85 | KDM4E (0.47) | GALR3MAPTKDM4ENPC1MAPK1 | |
| SCHEMBL23778062 | 0.83 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DCHRNA7 | |
| SCHEMBL8063014 | 0.81 | PDE4A (0.54) | PDE4BPDE4APDE4CPDE4DTDP1 | |
| SCHEMBL23788321 | 0.74 | SRD5A1 (0.38) | NPC1RAB9ACTSVCTSLSRD5A1 | |
| SCHEMBL9819174 | 0.73 | AKR1B1 (0.56) | PDE4BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19450185 | 0.73 | CTSV (0.56) | PDE4BPDE4APDE4CPDE4DCHRNA7 | |
| SCHEMBL8069101 | 0.72 | MAOB (0.47) | KDM4E | |
| SCHEMBL12067028 | 0.72 | MAOB (0.69) | MAPTKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL23778094 | 0.72 | MEN1 (0.41) | PDE4BCHRNA7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21052574 | 0.71 | CTSV (0.39) | PDE4BAGTR2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720857-B1 | 2-OXO-5H-CHROMENO[4,3-B]PYRIDINES FOR USE IN THE TREATMENT OF HEPATITIS B | GALAPAGOS NV (BE) | 2021-09-08 | — | — | EP | disclosed |
| EP-3720857-B1 | 2-OXO-5H-CHROMENO[4,3-B]PYRIDINES FOR USE IN THE TREATMENT OF HEPATITIS B | GALAPAGOS NV (BE) | 2021-09-08 | — | — | EP | disclosed |