Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179222 | 0.87 | MAPK1 (0.41) | HRH3IP6K1KCNH2 | |
| SCHEMBL20066058 | 0.87 | MAPK1 (0.41) | HRH3IP6K1KCNH2 | |
| SCHEMBL23778363 | 0.86 | MAP3K11 (0.40) | HRH3KCNH2 | |
| SCHEMBL23778441 | 0.82 | CALCRL (0.40) | HRH3 | |
| SCHEMBL23778244 | 0.81 | IP6K1 (0.36) | IP6K1 | |
| SCHEMBL23778385 | 0.77 | KDM4E (0.41) | HRH3 | |
| SCHEMBL23778382 | 0.76 | HRH3 (0.39) | HRH3IP6K1KCNH2 | |
| SCHEMBL20066059 | 0.75 | ALDH1A1 (0.42) | HRH3KCNH2 | |
| SCHEMBL30179623 | 0.75 | ALDH1A1 (0.42) | HRH3KCNH2 | |
| SCHEMBL23778450 | 0.75 | OPRM1 (0.48) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | claimed |
| CN-109996792-B | Heterocyclic compounds having activity as modulators of muscarinic M1 and/or M4 receptors in the treatment of CNS diseases and pain | 赫普泰雅治疗有限公司 | 2023-02-17 | — | — | CN | disclosed |