Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CCR5 | P51681 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23778250 | 1.00 | USP30 (0.39) | USP30MCHR1CYP2D6CCR5HRH3 | |
| SCHEMBL23778248 | 0.89 | CYP2D6 (0.43) | USP30MCHR1CYP2D6CCR5HRH3 | |
| SCHEMBL23778319 | 0.85 | HSD11B1 (0.45) | USP30CYP2D6CCR5HRH3KCNH2 | |
| SCHEMBL23778339 | 0.85 | HSD11B1 (0.45) | USP30CYP2D6CCR5HRH3KCNH2 | |
| SCHEMBL28954172 | 0.84 | CYP2D6 (0.37) | USP30MCHR1CYP2D6TACR3 | |
| SCHEMBL20066000 | 0.83 | USP30 (0.43) | USP30MCHR1CYP2D6HRH3TACR3 | |
| SCHEMBL23778331 | 0.82 | CCR5 (0.37) | USP30CYP2D6CCR5HRH3KCNH2 | |
| SCHEMBL23778432 | 0.82 | CCR5 (0.37) | USP30CYP2D6CCR5HRH3KCNH2 | |
| SCHEMBL23778286 | 0.81 | CCR5 (0.41) | USP30MCHR1CYP2D6CCR5HRH3 | |
| SCHEMBL23778237 | 0.81 | CYP2D6 (0.44) | USP30MCHR1CYP2D6CCR5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | claimed |