Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20066052 | 0.88 | POLB (0.45) | HRH3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL30179256 | 0.88 | POLB (0.45) | HRH3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL23778297 | 0.84 | HRH3 (0.39) | HRH3MAPK14 | |
| SCHEMBL23778450 | 0.84 | OPRM1 (0.48) | HRH3HTR7KDM4EALDH1A1 | |
| SCHEMBL23778440 | 0.82 | HRH3 (0.39) | HRH3KDM4EALDH1A1 | |
| SCHEMBL23778341 | 0.81 | MAPK14 (0.45) | HRH3MAPK14 | |
| SCHEMBL23778437 | 0.81 | PRKCB (0.34) | MAPK14HTR7KDM4E | |
| SCHEMBL23778330 | 0.80 | IP6K1 (0.39) | HRH3MAPK14ALDH1A1 | |
| SCHEMBL23778423 | 0.80 | HRH3 (0.37) | HRH3MAPK14L3MBTL1 | |
| SCHEMBL23778317 | 0.77 | MAPK14 (0.40) | HRH3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | claimed |