Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.34 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779084 | 0.92 | MAPK10 (0.39) | POLBMAPK10MAPK8MAPK14HRH4 | |
| SCHEMBL24321138 | 0.89 | MAPK10 (0.37) | POLBMAPK10MAPK8MAPK14PTGER1 | |
| SCHEMBL23779076 | 0.89 | HRH4 (0.48) | POLBMAPK10MAPK8MAPK14HRH4 | |
| SCHEMBL23779091 | 0.87 | POLB (0.43) | POLBMAPK10MAPK8MAPK14HRH4 | |
| SCHEMBL23779111 | 0.86 | MAPK1 (0.33) | HRH4GRM5KCNH2NAMPTKMT2A | |
| SCHEMBL23779092 | 0.82 | SYK (0.42) | POLBMAPK10MAPK8MAPK14HRH4 | |
| SCHEMBL23779102 | 0.81 | POLB (0.48) | POLBMAPK10MAPK8MAPK14HRH4 | |
| SCHEMBL23779078 | 0.81 | HRH4 (0.36) | POLBHRH4GRM5KCNH2KMT2A | |
| SCHEMBL23779073 | 0.78 | MMP9 (0.34) | HRH4GRM5KCNH2NAMPT | |
| SCHEMBL23779075 | 0.76 | POLB (0.53) | POLBMAPK14HRH4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-03-17 | — | — | US | disclosed |
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-03-17 | — | — | US | disclosed |
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | HCCS, CDK2, BRD4 | POLB 536/4885MAPK10 3488/4885MAPK8 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.