Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.38 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23779092 | 0.90 | SYK (0.42) | HRH4SYKPIP5K1CPIK3CAMAPK8 | |
| SCHEMBL23779042 | 0.89 | POLB (0.38) | HRH4PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL23779091 | 0.88 | POLB (0.43) | HRH4PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL23779102 | 0.87 | POLB (0.48) | HRH4PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL23779059 | 0.86 | HRH4 (0.46) | HRH4DRD2DRD3SYKMAPK14 | |
| SCHEMBL23779128 | 0.86 | HRH4 (0.39) | HRH4DRD2DRD3SYKPIP5K1C | |
| SCHEMBL23779084 | 0.84 | MAPK10 (0.39) | HRH4PIP5K1CPIK3CAMAPK8MAPK10 | |
| SCHEMBL23779075 | 0.83 | POLB (0.53) | HRH4MAPK14POLBNAMPT | |
| SCHEMBL23779068 | 0.81 | HRH4 (0.51) | HRH4DRD2DRD3MAPK14GRM5 | |
| SCHEMBL23779129 | 0.81 | HRH4 (0.51) | HRH4DRD2DRD3MAPK14GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |