Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319821 | 0.88 | POLB (0.39) | HRH4PIP5K1CPIK3CAPTGER1PIP5K1B | |
| SCHEMBL23779077 | 0.86 | HRH4 (0.38) | HRH4SYKPYGLPYGMDRD2 | |
| SCHEMBL23779076 | 0.86 | HRH4 (0.48) | HRH4PIP5K1CPIK3CAPTGER1SYK | |
| SCHEMBL23779040 | 0.79 | HRH4 (0.47) | HRH4PYGLPYGMDRD2DRD3 | |
| SCHEMBL23779092 | 0.78 | SYK (0.42) | HRH4PIP5K1CPIK3CAPTGER1SYK | |
| SCHEMBL24186747 | 0.76 | MALT1 (0.41) | PIP5K1CPIK3CAPTGER1MAPK8MAPK10 | |
| SCHEMBL23779042 | 0.75 | POLB (0.38) | HRH4PIP5K1CPIK3CAPTGER1PIP5K1B | |
| SCHEMBL23779091 | 0.74 | POLB (0.43) | HRH4PIP5K1CPIK3CAPTGER1PIP5K1B | |
| SCHEMBL23779097 | 0.73 | AKR1C3 (0.40) | HRH4DRD2DRD3GRM5 | |
| SCHEMBL23779102 | 0.73 | POLB (0.48) | HRH4PIP5K1CPIK3CAPIP5K1BMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-03-17 | — | — | US | disclosed |
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2022-03-17 | — | — | US | disclosed |
| EP-3873910-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2021-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081444-A1 | 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | HCCS, CDK2, BRD4 | HRH4 1121/4885PIP5K1C 1203/4885PIK3CA 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.