Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.46 |
| ▸ | PAM | P19021 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378112 | 1.00 | HDAC1 (0.46) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL28365595 | 0.80 | PPARA (0.62) | PAMACLYTBXAS1PPARAEGFR | |
| SCHEMBL3795388 | 0.78 | SIGMAR1 (0.50) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL9303907 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL849354 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL11315341 | 0.76 | HDAC1 (0.57) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL849353 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL5176079 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL8093646 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL8093649 | 0.76 | TBXAS1 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026280-B2 | For therapy of cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy. | ERRANT GENE THERAPEUTICS, LLC (US) | 2011-09-27 | — | — | US | claimed |
| EP-0790824-B1 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-06 | — | — | EP | disclosed |
| US-5968982-A | TREATMENT OF DIABETES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-10-19 | — | — | US | disclosed |