Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | GPR52 | Q9Y2T5 | 4/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378147 | 1.00 | TOP1 (0.72) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL10986050 | 1.00 | TOP1 (0.72) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7991496 | 0.95 | TOP1 (0.65) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL10533519 | 0.93 | TOP1 (0.72) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL6758436 | 0.89 | KEAP1 (0.63) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7738550 | 0.89 | KEAP1 (0.63) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL7738555 | 0.89 | KEAP1 (0.63) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL6759998 | 0.89 | KEAP1 (0.63) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL6758432 | 0.89 | KEAP1 (0.63) | TOP1HDAC3MAPK1ADRA1AHDAC4 | |
| SCHEMBL6763471 | 0.87 | MAPT (0.70) | TOP1HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026280-B2 | For therapy of cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy. | ERRANT GENE THERAPEUTICS, LLC (US) | 2011-09-27 | — | — | US | claimed |
| WO-2009113320-A1 | MMP INHIBITOR | 株式会社ヤクルト本社 (JP) | 2009-09-17 | — | — | WO | disclosed |
| US-4513005-A | SULFIDE OR SULFONE HYDROXY ACIDS | LILLY INDUSTRIES LIMITED (GB) | 1985-04-23 | — | — | US | disclosed |
| EP-0068739-B1 | SULPHUR-CONTAINING 5-HYDROXY-ALKANOIC ACID DERIVATIVES, THEIR USE AS PHARMACEUTICAL PREPARATIONS AND PROCESS FOR THEIR PRODUCTION | Lilly Industries Limited (GB) | 1984-11-14 | — | — | EP | disclosed |
| EP-0068739-A1 | Sulphur-containing 5-hydroxy-alkanoic acid derivatives, their use as pharmaceutical preparations and process for their production | Lilly Industries Limited (GB) | 1983-01-05 | — | — | EP | disclosed |