Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808225 | 0.78 | LRRK2 (0.49) | LRRK2HTR6PPARDPPARADRD2 | |
| SCHEMBL6810848 | 0.77 | ESR1 (0.43) | LRRK2HTR6PPARDPPARAPGR | |
| SCHEMBL4517438 | 0.76 | PGR (0.58) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL29741012 | 0.76 | PGR (0.58) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL4142468 | 0.76 | PGR (0.58) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL31741085 | 0.73 | CYP11B2 (0.49) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL4526621 | 0.73 | CYP11B2 (0.49) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL4142891 | 0.73 | CYP11B2 (0.49) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL4138513 | 0.73 | LRRK2 (0.43) | LRRK2HTR6DRD2DRD3PNMT | |
| SCHEMBL14072565 | 0.73 | LRRK2 (0.46) | LRRK2HTR6DRD2DRD3PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155419-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2022-07-21 | — | — | WO | disclosed |
| WO-2021178780-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |