Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | THRB | P10828 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | RECQL | P46063 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | BLM | P54132 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23787624 | 0.91 | ALDH1A1 (0.62) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787576 | 0.85 | THRB (0.64) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787736 | 0.84 | PHLPP2 (0.50) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787779 | 0.83 | THRB (0.41) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787678 | 0.83 | PHLPP2 (0.55) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787517 | 0.83 | ALDH1A1 (0.50) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787546 | 0.83 | ALDH1A1 (0.53) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787787 | 0.83 | THRB (0.43) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787636 | 0.81 | ALDH1A1 (0.56) | ALDH1A1THRBHPGDRECQLMEN1 | |
| SCHEMBL23787577 | 0.79 | ALDH1A1 (0.65) | ALDH1A1THRBHPGDRECQLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI (TR) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | POLG, POLB, POLA1 | ALDH1A1 3745/4885THRB 2774/4885HPGD 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.