Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | THRB | P10828 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 3/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.54 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23787719 | 0.92 | MEN1 (0.57) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787779 | 0.85 | THRB (0.41) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787783 | 0.85 | THRB (0.56) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787668 | 0.84 | THRB (0.57) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787584 | 0.84 | PHLPP2 (0.65) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787619 | 0.82 | THRB (0.66) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787532 | 0.82 | ALDH1A1 (0.44) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL19154349 | 0.82 | THRB (0.66) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787576 | 0.82 | THRB (0.64) | HPGDCYP3A4ALDH1A1THRBRECQL | |
| SCHEMBL23787778 | 0.82 | ALDH1A1 (0.46) | HPGDCYP3A4ALDH1A1THRBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI (TR) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | POLG, POLB, POLA1 | HPGD 1140/4885CYP3A4 4334/4885ALDH1A1 3745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.