Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.52 |
| ▸ | MPL | P40238 | 3/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23787551 | 0.92 | PHLPP2 (0.54) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787730 | 0.88 | ENPP2 (0.46) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787696 | 0.85 | PHLPP2 (0.57) | PHLPP2CYP2C9MAPK1MEN1KMT2A | |
| SCHEMBL23787674 | 0.83 | PHLPP2 (0.49) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787585 | 0.83 | PHLPP2 (0.63) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787644 | 0.83 | CYP1A2 (0.47) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787737 | 0.81 | MPL (0.54) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787586 | 0.81 | MPL (0.54) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787792 | 0.80 | PHLPP2 (0.53) | PHLPP2MPLCTRCCYP1A2CYP2C9 | |
| SCHEMBL23787548 | 0.80 | ENPP2 (0.48) | PHLPP2MPLCTRCCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI (TR) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210275548-A1 | NOVEL DNA POLYMERASE GAMMA INHIBITOR AND USES THEREOF | POLG, POLB, POLA1 | PHLPP2 1195/4885MPL 2115/4885CTRC 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.