Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9945905 | 0.84 | ACHE (0.33) | ACHE | |
| SCHEMBL19682787 | 0.80 | ACHE (0.31) | ACHE | |
| SCHEMBL3093413 | 0.80 | MEN1 (0.33) | ACHE | |
| SCHEMBL23046939 | 0.78 | MET (0.31) | — | |
| SCHEMBL23101924 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL19682362 | 0.77 | SLC7A5 (0.35) | — | |
| SCHEMBL20889379 | 0.77 | SLC7A5 (0.35) | — | |
| SCHEMBL21612984 | 0.76 | ACHE (0.46) | ACHE | |
| SCHEMBL16103807 | 0.74 | ACHE (0.30) | ACHE | |
| SCHEMBL23101959 | 0.74 | GAA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380471-B1 | TETRAHYDRO-8H-PYRIDO[1,2-A]PYRAZINE-8-ONES AS COMT INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | LIEBER INST INC DBA LIEBER INST FOR BRAIN DEVELOPMENT (US) | 2021-09-08 | — | — | EP | disclosed |