Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381106 | 1.00 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2378891 | 1.00 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2381104 | 1.00 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL12245785 | 0.86 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL10198759 | 0.86 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL5376359 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL13859924 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL5376363 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL2380086 | 0.85 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatin SCHEMBL19886 | 0.84 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237832-A1 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-09-29 | — | — | US | claimed |
| US-20110237832-A1 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237832-A1 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES | HDAC1, HDAC8, HDAC4 | HDAC1 1/4885HDAC3 9/4885HDAC4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.