Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trichostatic Acid SCHEMBL5376359 | 1.00 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL5376363 | 1.00 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatic Acid SCHEMBL13859924 | 1.00 | HDAC1 (0.74) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL12245785 | 0.90 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL13859923 | 0.87 | HDAC1 (0.72) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8237213 | 0.87 | HDAC1 (0.72) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2381104 | 0.85 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatin SCHEMBL19886 | 0.85 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL2378893 | 0.85 | HDAC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Trichostatin SCHEMBL446807 | 0.85 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237832-A1 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-09-29 | — | — | US | claimed |
| US-7235688-B1 | Process for preparing histone deacetylase inhibitors and intermediates thereof | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2007-06-26 | — | — | US | claimed |
| US-20070021612-A1 | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2007-01-25 | — | — | US | claimed |
| EP-0331524-B1 | SYNTHESIS OF TRICHOSTATINS | Japan Tobacco Inc. (JP) | 1993-08-18 | — | — | EP | claimed |
| EP-0331524-A2 | Synthesis of trichostatins | Japan Tobacco Inc. (JP) | 1989-09-06 | — | — | EP | claimed |
| JP-1224381-A | — | — | None | — | — | JP | disclosed |
| JP-1224381-A | — | — | None | — | — | JP | disclosed |
| US-11421223-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. (US) | 2022-08-23 | — | — | US | disclosed |
| US-20190309289-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2019-10-10 | — | — | US | disclosed |
| US-10370654-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180320170-A1 | PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING | ENEVOLV, INC. | 2018-11-08 | — | — | US | disclosed |
| US-9944925-B2 | Processes and host cells for genome, pathway, and biomolecular engineering | ENEVOLV, INC. | 2018-04-17 | — | — | US | disclosed |
| EP-0331524-B1 | SYNTHESIS OF TRICHOSTATINS | Japan Tobacco Inc. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-4946999-A | Novel intermediates for synthesis of trichostatic acid or trichostatin A, and processes for preparing trichostatic acid and trichostatin A | JAPAN TOBACCO INC. (JP) | 1990-08-07 | — | — | US | disclosed |
| US-4946999-A | Novel intermediates for synthesis of trichostatic acid or trichostatin A, and processes for preparing trichostatic acid and trichostatin A | JAPAN TOBACCO INC. (JP) | 1990-08-07 | — | — | US | disclosed |
| US-4946999-A | Novel intermediates for synthesis of trichostatic acid or trichostatin A, and processes for preparing trichostatic acid and trichostatin A | JAPAN TOBACCO INC. (JP) | 1990-08-07 | — | — | US | disclosed |
| JP-H01224381-A | TRICHOSTATIC ACID, NOVEL SYNTHETIC INTERMEDIATE FOR TRICHOSTATIN A AND PRODUCTION OF TRICHOSTATIC ACID AND TRICHOSTATIN A | JAPAN TOBACCO INC | 1989-09-07 | — | — | JP | disclosed |
| JP-H01224381-A | TRICHOSTATIC ACID, NOVEL SYNTHETIC INTERMEDIATE FOR TRICHOSTATIN A AND PRODUCTION OF TRICHOSTATIC ACID AND TRICHOSTATIN A | JAPAN TOBACCO INC | 1989-09-07 | — | — | JP | disclosed |
| EP-0331524-A2 | Synthesis of trichostatins | Japan Tobacco Inc. (JP) | 1989-09-06 | — | — | EP | disclosed |
| EP-0331524-A2 | Synthesis of trichostatins | Japan Tobacco Inc. (JP) | 1989-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021612-A1 | Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC3 6/4885HDAC4 11/4885 |
| US-20110237832-A1 | SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES | HDAC1, HDAC8, HDAC4 | HDAC1 1/4885HDAC3 9/4885HDAC4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.