Trichostatin

Trichostatin

SCHEMBL19886

CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)c1ccc(N(C)C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 16/20 1.00
HDAC6 Q9UBN7 12/20 1.00
HDAC3 O15379 10/20 1.00
HDAC4 P56524 10/20 1.00
HDAC7 Q8WUI4 10/20 1.00
HDAC2 Q92769 10/20 1.00
HDAC10 Q969S8 10/20 1.00
HDAC8 Q9BY41 10/20 1.00
HDAC9 Q9UKV0 10/20 1.00
HDAC5 Q9UQL6 10/20 1.00
HDAC11 Q96DB2 9/20 1.00
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
TLR9 Q9NR96 1/20 0.41
TOP2A P11388 1/20 0.40
MAPT P10636 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trichostatin SCHEMBL446807 1.00 HDAC1 (1.00) HDAC1HDAC6HDAC3HDAC4HDAC7
Trichostatin SCHEMBL675951 1.00 HDAC1 (1.00) HDAC1HDAC6HDAC3HDAC4HDAC7
Trichostatin SCHEMBL446806 1.00 HDAC1 (1.00) HDAC1HDAC6HDAC3HDAC4HDAC7
Trichostatin SCHEMBL16380793 1.00 HDAC1 (1.00) HDAC1HDAC6HDAC3HDAC4HDAC7
Trichostatin SCHEMBL29450582 0.99 HDAC1 (0.97) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL21965902 0.91 HDAC1 (0.83) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL10324242 0.90 HDAC1 (0.81) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL17119540 0.88 HDAC1 (0.79) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL14392626 0.87 HDAC1 (0.77) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL13301372 0.87 HDAC1 (0.77) HDAC1HDAC6HDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 24924 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747363-A1 NEURAL DIFFERENTIATION FROM PLURIPOTENT CELLS Treefrog Therapeutics (FR) 2026-05-27 EP claimed
CN-122075711-A Application of histone deacetylase inhibitor HDACi in preparation of medicines for preventing and/or treating ammonia-induced encephalopathy 2026-05-26 CN claimed
US-12637685-B2 Method for rapid genome modification in recalcitrant plants KWS SAAT SE & Co. KGaA (DE) 2026-05-26 US claimed
US-12637498-B2 PDLIM2 as a biomarker for cancer and as an anti-cancer treatment target University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2026-05-26 US claimed
WO-2026106917-A1 EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL BioPhysics Pharma, Inc. (US) 2026-05-21 WO claimed
WO-2026107052-A1 COMBINATION TREATMENTS USING EPIGENETIC INHIBITION AND SYNGRI-MEDIATED FRATAXIN EXPRESSION ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) 2026-05-21 WO claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
CN-122057026-A Pharmaceutical composition for treating multiple myeloma and application thereof 南京鼓楼医院 2026-05-19 CN claimed
CN-122038275-A Method for inducing mesenchymal stem cells to differentiate into islet-like cells and application thereof 天津市康婷生物工程集团有限公司 2026-05-15 CN claimed
US-12628581-B2 Substrate processing method ASM IP HOLDING B.V. (NL) 2026-05-12 US claimed
WO-1998029108-A2 COMPOSITIONS AND METHODS FOR RESTORING A NORMAL PATTERN OF IMPRINTING TO CELLS THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1998-07-09 WO claimed
EP-0827742-A1 Use of histone deacetylase inhibitors for treating fribosis or cirrhosis VRIJE UNIVERSITEIT BRUSSEL (BE) 1998-03-11 EP claimed
EP-0827743-A1 Use of histone decarboxylase inhibitors for treating fibrosis VRIJE UNIVERSITEIT BRUSSEL (BE) 1998-03-11 EP claimed
WO-1997047307-A1 USE OF HISTONE DEACETYLASE INHIBITORS TO ACTIVATE TRANSGENE EXPRESSION THE UAB RESEARCH FOUNDATION (US) 1997-12-18 WO claimed
EP-0649900-A2 Process for production of protein SUNTORY LIMITED (JP) 1995-04-26 EP claimed
EP-0331524-B1 SYNTHESIS OF TRICHOSTATINS Japan Tobacco Inc. (JP) 1993-08-18 EP claimed
EP-0196415-B1 TRICHOSTATINS A AND C AS ANTITUMOUR DRUGS Beppu, Teruhiko (JP) 1991-10-23 EP claimed
EP-0331524-A2 Synthesis of trichostatins Japan Tobacco Inc. (JP) 1989-09-06 EP claimed
US-4690918-A Use of trichostatin compounds for treating tumor cells Beppu, Teruhiko (JP) 1987-09-01 US claimed
EP-0196415-A2 Trichostatins A and C as antitumour drugs Beppu, Teruhiko (JP) 1986-10-08 EP claimed