⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9294490 | 0.68 | — | — | |
| SCHEMBL4799069 | 0.65 | NOTUM (0.43) | — | |
| SCHEMBL14754530 | 0.64 | — | — | |
| SCHEMBL9039149 | 0.64 | ADRA2A (0.31) | — | |
| SCHEMBL9565996 | 0.64 | — | — | |
| SCHEMBL5072580 | 0.62 | — | — | |
| SCHEMBL908521 | 0.62 | — | — | |
| SCHEMBL122102 | 0.62 | — | — | |
| SCHEMBL4108957 | 0.62 | — | — | |
| SCHEMBL538437 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281296-A1 | Compunds and processes that generate cyclopropenes and substituted cyclopropenes on demand | STEVENSON CHERYL D (US) | 2013-10-24 | — | — | US | claimed |
| WO-2012128780-A1 | COMPOUNDS AND PROCESSES THAT GENERATE CYCLOPROPENES AND SUBSTTITUTED CYCLOPROPENES ON DEMAND | PRAGMACHEM LLC (US) | 2012-09-27 | — | — | WO | claimed |
| US-20110232178-A1 | Compounds and processes that generate cyclopropenes and substituted cyclopropenes on demand | DAVIS JOHN PERRIN | 2011-09-29 | — | — | US | claimed |
| EP-4630405-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024123815-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-06-13 | — | — | WO | disclosed |
| CN-117858875-A | Hydroxy-and (halo) alkoxy-substituted tetrahydrofurans as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-09 | — | — | CN | disclosed |