Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 4/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378764 | 0.85 | FUCA1 (0.49) | FUCA1KDM1AMAOAOPRM1OPRL1 | |
| SCHEMBL7213327 | 0.80 | OPRM1 (0.57) | OPRM1OPRL1GRIN2BBCHEACHE | |
| SCHEMBL14418800 | 0.76 | KDM4E (0.56) | FUCA1KDM1AMAOAGRIN2BKDM4E | |
| SCHEMBL13259009 | 0.76 | KDM4E (0.56) | FUCA1KDM1AMAOAGRIN2BKDM4E | |
| SCHEMBL21744620 | 0.76 | OPRM1 (0.65) | OPRM1OPRL1GRIN2BBCHEACHE | |
| SCHEMBL12203638 | 0.76 | KDM4E (0.56) | FUCA1KDM1AMAOAGRIN2BKDM4E | |
| SCHEMBL15489529 | 0.76 | KDM4E (0.56) | FUCA1KDM1AMAOAGRIN2BKDM4E | |
| SCHEMBL12460806 | 0.76 | KDM4E (0.56) | FUCA1KDM1AMAOAGRIN2BKDM4E | |
| SCHEMBL25069529 | 0.75 | FUCA1 (0.72) | FUCA1KDM1AMAOAGRIN2B | |
| SCHEMBL18828620 | 0.75 | FUCA1 (0.72) | FUCA1KDM1AMAOAGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102232076-B | Pyrrolopyrazinyl urea kinase inhibitors | HOFFMANN LA ROCHE | 2014-12-31 | — | — | CN | disclosed |
| EP-2373653-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| US-8012974-B2 | Pyrrolopyrazinyl urea kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-09-06 | — | — | US | disclosed |
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | ROCHE PALO ALTO LLC | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | JAK1, JAK3, ULK3 | FUCA1 4039/4885KDM1A 669/4885MAOA 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.