Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389864 | 1.00 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2HCRTR1HCRTR2 | |
| SCHEMBL12290387 | 0.86 | PDE4B (0.38) | TAS1R3TAS1R1TAS1R2HCRTR1HCRTR2 | |
| SCHEMBL2391396 | 0.83 | ALDH1A1 (0.39) | TAS1R3TAS1R1TAS1R2HCRTR1HCRTR2 | |
| SCHEMBL25937283 | 0.79 | HCRTR1 (0.40) | HCRTR1HCRTR2F2RPDE4BHDAC4 | |
| SCHEMBL25937280 | 0.79 | HCRTR1 (0.40) | HCRTR1HCRTR2F2RPDE4BHDAC4 | |
| SCHEMBL2390297 | 0.78 | KDM1A (0.41) | KDM4DHDAC1HDAC2RORCKDM1A | |
| SCHEMBL25117972 | 0.74 | SSTR4 (0.38) | HCRTR1HCRTR2F2RPDE4BHDAC4 | |
| SCHEMBL20987891 | 0.74 | KDM1A (0.50) | HDAC4HDAC6KDM1AKMT2AL3MBTL1 | |
| SCHEMBL27280486 | 0.74 | HCRTR1 (0.36) | TAS1R3TAS1R1TAS1R2HCRTR1HCRTR2 | |
| SCHEMBL29424933 | 0.73 | AAK1 (0.39) | TAS1R3TAS1R1TAS1R2F2RPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539345-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO]THIENO [2, 3 - D]PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104334-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO] THIENO [2, 3 - D] PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-01 | — | — | WO | disclosed |