Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782503 | 0.90 | NOTUM (0.44) | DHODHNOTUMRORBKDM4ERAPGEF3 | |
| SCHEMBL30176220 | 0.90 | NOTUM (0.44) | DHODHNOTUMRORBKDM4ERAPGEF3 | |
| SCHEMBL23791928 | 0.89 | DHODH (0.41) | DHODHNOTUMKDM4EMEN1KMT2A | |
| SCHEMBL23782583 | 0.88 | DHODH (0.49) | DHODHNOTUMRORBKDM4ELMNA | |
| SCHEMBL30173735 | 0.88 | DHODH (0.49) | DHODHNOTUMRORBKDM4ELMNA | |
| SCHEMBL30173780 | 0.80 | DHODH (0.47) | DHODHRORBRAPGEF3RAPGEF4MEN1 | |
| SCHEMBL23782602 | 0.80 | DHODH (0.47) | DHODHRORBRAPGEF3RAPGEF4MEN1 | |
| SCHEMBL26241854 | 0.79 | MAPT (0.39) | DHODHNOTUMKDM4EMEN1KMT2A | |
| SCHEMBL23792390 | 0.79 | KDM4E (0.41) | DHODHNOTUMKDM4EMEN1KMT2A | |
| SCHEMBL23782403 | 0.79 | NOTUM (0.43) | DHODHNOTUMRORBKDM4ERAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178488-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |