Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369799 | 0.92 | ALDH1A1 (0.42) | FAAHACHEALDH1A1MAPTTDP1 | |
| SCHEMBL2391267 | 0.86 | TDP1 (0.40) | FAAHACHEALDH1A1MAPTTDP1 | |
| Trifluoroacetic Acid SCHEMBL2388889 | 0.83 | FAAH (0.40) | FAAHACHEALDH1A1MAPTTDP1 | |
| SCHEMBL2370254 | 0.81 | TDP1 (0.44) | FAAHACHEALDH1A1MAPTTDP1 | |
| SCHEMBL25346294 | 0.80 | TDP1 (0.51) | FAAHACHEALDH1A1MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL2369289 | 0.80 | PRKCQ (0.42) | FAAHACHEALDH1A1MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL2369725 | 0.80 | PRKCQ (0.42) | FAAHACHEALDH1A1MAPTTDP1 | |
| Hydrochloric Acid SCHEMBL2369727 | 0.80 | PRKCQ (0.42) | FAAHACHEALDH1A1MAPTTDP1 | |
| SCHEMBL12256912 | 0.80 | TDP1 (0.43) | FAAHACHEALDH1A1MAPTTDP1 | |
| SCHEMBL2388891 | 0.79 | FAAH (0.42) | FAAHACHEALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539345-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO]THIENO [2, 3 - D]PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104334-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO] THIENO [2, 3 - D] PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-01 | — | — | WO | disclosed |