Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 6/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930604 | 0.90 | USP2 (0.59) | USP2CYP2C19CYP1A2FAAHSIGMAR1 | |
| SCHEMBL23111591 | 0.85 | USP2 (0.51) | USP2CYP2C19CYP1A2FAAHSIGMAR1 | |
| SCHEMBL447202 | 0.83 | CYP2D6 (0.53) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL545692 | 0.81 | ALDH1A1 (0.58) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL29967920 | 0.81 | ALDH1A1 (0.58) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL4935986 | 0.81 | ALDH1A1 (0.54) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL29777509 | 0.80 | LMNA (0.53) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL545449 | 0.80 | LMNA (0.53) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL545422 | 0.80 | ALDH1A1 (0.47) | USP2CYP2C19CYP1A2TSHRCYP2D6 | |
| SCHEMBL29543344 | 0.80 | ALDH1A1 (0.47) | USP2CYP2C19CYP1A2TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877371-A1 | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-15 | — | — | EP | disclosed |