Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 3/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 4/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23796227 | 0.83 | TRPV1 (0.43) | MAP4K4TRPV1CLK1CDK5CDK5R1 | |
| SCHEMBL2224558 | 0.79 | MAP4K4 (0.57) | MAP4K4TRPV1CLK1USP7CDK5 | |
| SCHEMBL23795928 | 0.73 | BACE1 (0.41) | TRPV1CLK1FEN1ALOX5APKIF11 | |
| SCHEMBL23796122 | 0.71 | KMT2A (0.37) | TRPV1CLK1FEN1ALOX5APTHRB | |
| SCHEMBL26711827 | 0.71 | TOP1 (0.50) | MAP4K4CLK1USP7CDK5CDK5R1 | |
| SCHEMBL1348639 | 0.71 | MAP4K4 (0.55) | MAP4K4TRPV1CLK1USP7FEN1 | |
| SCHEMBL8981695 | 0.70 | MAP4K4 (0.57) | MAP4K4USP7FEN1ALOX5APKIF11 | |
| SCHEMBL23796415 | 0.69 | MAOB (0.38) | TRPV1KIF11 | |
| SCHEMBL23796457 | 0.69 | MAOB (0.43) | TRPV1XDHALDH1A1 | |
| SCHEMBL29655508 | 0.69 | DHFR (0.55) | MAP4K4CLK1CDK5CDK5R1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877356-A1 | BICYCLIC COMPOUNDS | Vivace Therapeutics, Inc. (US) | 2021-09-15 | — | — | EP | disclosed |
| CN-113302175-A | Bicyclic compounds | 维瓦斯治疗公司 | 2021-08-24 | — | — | CN | disclosed |