Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68112 | 0.87 | DGAT1 (0.41) | DGAT1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL22234417 | 0.85 | DGAT1 (0.40) | DGAT1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL23781145 | 0.82 | DGAT1 (0.38) | DGAT1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL22470948 | 0.78 | MAPK14 (0.44) | DGAT1 | |
| SCHEMBL23797464 | 0.77 | DGAT1 (0.44) | DGAT1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL67447 | 0.75 | DGAT1 (0.40) | DGAT1KDM4ETSHRMAPTALDH1A1 | |
| SCHEMBL67109 | 0.75 | TNIK (0.43) | DGAT1MAPT | |
| SCHEMBL6982067 | 0.74 | DGAT1 (0.58) | DGAT1ALDH1A1HPGD | |
| SCHEMBL66909 | 0.74 | DGAT1 (0.47) | DGAT1KDM4ETHRBALDH1A1CASR | |
| SCHEMBL68153 | 0.72 | MAPK14 (0.39) | DGAT1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876928-A2 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-09-15 | — | — | EP | disclosed |