Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073673 | 0.80 | DGAT1 (0.41) | DGAT1KDM4ETSHRMAPTALDH1A1 | |
| SCHEMBL68112 | 0.79 | DGAT1 (0.41) | DGAT1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL16828763 | 0.79 | DGAT1 (0.41) | DGAT1KMT2AMAPTNPC1 | |
| SCHEMBL15572246 | 0.77 | DGAT1 (0.40) | DGAT1MAPTNPC1 | |
| SCHEMBL22234417 | 0.77 | DGAT1 (0.40) | DGAT1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL23797282 | 0.77 | DGAT1 (0.40) | DGAT1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL16787698 | 0.76 | DGAT1 (0.50) | DGAT1KDM4EMAPTPPARDALOX5AP | |
| SCHEMBL21838857 | 0.75 | DGAT1 (0.41) | DGAT1KDM4ETSHRMAPTNPC1 | |
| SCHEMBL15986164 | 0.75 | MAPT (0.38) | DGAT1KDM4ETSHRMAPTALDH1A1 | |
| SCHEMBL31457411 | 0.75 | DGAT1 (0.38) | DGAT1MAPTALDH1A1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3876928-A2 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-09-15 | — | — | EP | disclosed |