Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 8/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30398620 | 0.83 | USP30 (0.47) | PRMT5WDR77BACE1 | |
| SCHEMBL31500593 | 0.82 | LPL (0.38) | LPLLIPGROCK1IRAK4 | |
| SCHEMBL31315352 | 0.80 | IDO1 (0.40) | IDO1TDO2CSF1RPRMT5WDR77 | |
| SCHEMBL16651441 | 0.80 | IDO1 (0.40) | IDO1TDO2CSF1RPRMT5WDR77 | |
| SCHEMBL20808708 | 0.80 | PRMT5 (0.41) | IDO1TDO2CSF1RPRMT5WDR77 | |
| SCHEMBL28669020 | 0.79 | IRAK4 (0.42) | DHODHLPLLIPGROCK1IRAK4 | |
| SCHEMBL22551912 | 0.79 | DHODH (0.36) | DHODHCSF1RPRMT5WDR77LPL | |
| SCHEMBL28681721 | 0.78 | PRMT5 (0.36) | IDO1TDO2CSF1RPRMT5WDR77 | |
| SCHEMBL24145842 | 0.77 | IDO1 (0.38) | IDO1TDO2CSF1RPRMT5WDR77 | |
| SCHEMBL565362 | 0.77 | GRM2 (0.39) | LPLLIPGROCK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113874354-B | Pyridone derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-113874354-A | Pyridone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-12-31 | — | — | CN | disclosed |
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2021-12-30 | — | — | US | disclosed |
| EP-3876928-A2 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | Merck Sharp & Dohme Corp. (US) | 2021-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | HDAC1, HDAC11, HDAC3 | IDO1 319/4885TDO2 3540/4885DHODH 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.