Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 4/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23798468 | 0.79 | GPR119 (0.45) | — | |
| SCHEMBL21227703 | 0.77 | SIRT3 (0.54) | SIRT3TDP1SMYD3 | |
| SCHEMBL21227634 | 0.74 | SIRT3 (0.51) | SIRT3TDP1SMYD3TSHR | |
| SCHEMBL25102680 | 0.73 | SIRT3 (0.50) | SIRT3TDP1SMYD3 | |
| SCHEMBL14907222 | 0.70 | SIRT3 (0.61) | SIRT3TDP1 | |
| SCHEMBL4086407 | 0.70 | SIRT3 (0.46) | SIRT3TDP1SMYD3MKNK1MKNK2 | |
| SCHEMBL15563693 | 0.69 | SIRT3 (0.59) | SIRT3TDP1MKNK1MKNK2 | |
| SCHEMBL22318560 | 0.68 | ALDH1A1 (0.48) | OPRD1OPRM1MKNK1MKNK2KCNA5 | |
| SCHEMBL12310852 | 0.67 | SIRT3 (0.49) | SIRT3TDP1SMYD3 | |
| SCHEMBL22318107 | 0.67 | SIRT3 (0.37) | SIRT3TDP1SMYD3TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178920-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 | C4 THERAPEUTICS, INC. (US) | 2021-09-10 | — | — | WO | disclosed |