Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20066008 | 0.87 | CYP2D6 (0.48) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20073973 | 0.86 | POLB (0.48) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20066038 | 0.85 | HSD11B1 (0.48) | POLBMAPK1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL20066073 | 0.85 | CYP2D6 (0.49) | POLBMAPK1KDM4EALDH1A1LMNA | |
| SCHEMBL24609048 | 0.83 | MEN1 (0.49) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23798655 | 0.82 | MAPK1 (0.43) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20066015 | 0.80 | GAA (0.46) | POLBMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL20066013 | 0.79 | POLB (0.48) | POLBMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20066007 | 0.78 | HRH3 (0.51) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL20066010 | 0.78 | MEN1 (0.51) | MAPK1KDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | disclosed |