Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930268 | 0.76 | KDM4E (0.35) | BTKRXFP1KDM4EMAPTALDH1A1 | |
| SCHEMBL14912399 | 0.75 | MAP4K4 (0.36) | BTKRXFP1KDM4EMAPTALDH1A1 | |
| SCHEMBL19965804 | 0.74 | BTK (0.38) | BTKRXFP1KDM4EMAPTALDH1A1 | |
| SCHEMBL23652719 | 0.73 | HDAC6 (0.41) | BTKRXFP1KDM4EMAPTALDH1A1 | |
| SCHEMBL14913421 | 0.70 | CYP2D6 (0.36) | BTKRXFP1KDM4EMAPTALDH1A1 | |
| SCHEMBL14912161 | 0.68 | EHMT2 (0.34) | KDM4EMAPTALDH1A1 | |
| SCHEMBL17147100 | 0.66 | ACHE (0.35) | RXFP1KDM4EMAPTALDH1A1USP2 | |
| SCHEMBL14912888 | 0.63 | POLB (0.34) | KDM4EALDH1A1MAPK1RAB9A | |
| SCHEMBL14912100 | 0.62 | BTK (0.45) | BTK | |
| SCHEMBL15297035 | 0.60 | FYN (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521288-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2021-09-08 | — | — | EP | disclosed |