Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381684 | 0.95 | DRD2 (0.56) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2379476 | 0.94 | DRD2 (0.55) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2381465 | 0.92 | DRD2 (0.69) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2380237 | 0.90 | CHRM1 (0.62) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2369600 | 0.86 | DRD2 (0.67) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL20959758 | 0.86 | CHRM1 (0.66) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2159505 | 0.85 | CHRM1 (0.56) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL2159671 | 0.85 | CHRM1 (0.56) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL12395969 | 0.85 | CHRM1 (0.56) | DRD2CHRM1LMNACHRM2CHRM4 | |
| SCHEMBL19161081 | 0.85 | DRD2 (0.53) | DRD2CHRM1LMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3476218-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2019-05-01 | — | — | EP | disclosed |
| US-9889198-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890150-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170246301-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170247368-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170042906-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-02-16 | — | — | US | disclosed |
| US-9511149-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20150044261-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2015-02-12 | — | — | US | disclosed |
| US-8900604-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130158007-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | KEMPHARM, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130045247-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM INC. | 2013-02-21 | — | — | US | disclosed |
| EP-2544536-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-09-15 | — | — | US | disclosed |
| WO-2011112657-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246301-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20150044261-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20170042906-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20130045247-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20130158007-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
| US-20170247368-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885CHRM1 1291/4885LMNA 1944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.