Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.44 |
| ▸ | MTOR | P42345 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072220 | 0.90 | SMN1; SMN2 (0.45) | SMN1; SMN2PIK3CAPIK3R1MTORKDM4E | |
| SCHEMBL23804721 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2PIK3CAPIK3R1MTORKDM4E | |
| SCHEMBL24711007 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2PIK3CAPIK3R1KDM4EALDH1A1 | |
| SCHEMBL30151166 | 0.81 | PIK3CA (0.44) | SMN1; SMN2PIK3CAPIK3R1MTORALDH1A1 | |
| SCHEMBL12727282 | 0.81 | PIK3CA (0.46) | SMN1; SMN2PIK3CAPIK3R1MTORALDH1A1 | |
| SCHEMBL1180841 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PIK3CAKDM4EALDH1A1GAA | |
| SCHEMBL14385000 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL23804768 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPIK3R1KDM4EALDH1A1 | |
| SCHEMBL31283486 | 0.79 | MAPT (0.40) | SMN1; SMN2PIK3CAPIK3R1MTORKDM4E | |
| SCHEMBL2674386 | 0.79 | HRH3 (0.41) | SMN1; SMN2PIK3CAPIK3R1MTORKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230146395-A1 | Substituted Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230146395-A1 | Substituted Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230146395-A1 | Substituted Pyrimidines and Uses Thereof | Verge Analytics, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4118087-A1 | SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2023-01-18 | — | — | EP | disclosed |
| WO-2022261068-A1 | METHODS AND TREATMENT OF VIRAL INFECTION WITH SUBSTITUTED FURO-PYRIMIDINES | Verge Analytics, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2021183439-A1 | SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2021-09-16 | — | — | WO | disclosed |
| WO-2021183439-A1 | SUBSTITUTED FURO[3,2-D]PYRIMIDINES AND USES THEREOF | Verge Analytics, Inc. (US) | 2021-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230146395-A1 | Substituted Pyrimidines and Uses Thereof | PIKFYVE, PIK3CA, PIK3CB | SMN1; SMN2 170/4885PIK3CA 2/4885PIK3R1 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.