Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23804692 | 0.90 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPIK3R1PIK3CDKDM4E | |
| SCHEMBL23804721 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2PIK3CAPIK3R1PIK3CDKDM4E | |
| SCHEMBL24711007 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2PIK3CAPIK3R1PIK3CDKDM4E | |
| SCHEMBL30151166 | 0.79 | PIK3CA (0.44) | SMN1; SMN2PIK3CAPIK3R1PIK3CDALDH1A1 | |
| SCHEMBL12727282 | 0.79 | PIK3CA (0.46) | SMN1; SMN2PIK3CAPIK3R1PIK3CDALDH1A1 | |
| SCHEMBL1180841 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2PIK3CAKDM4EMAPK1ALDH1A1 | |
| SCHEMBL14385000 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPK1ALDH1A1GAA | |
| SCHEMBL4076548 | 0.78 | PIK3CA (0.60) | SMN1; SMN2PIK3CAPIK3R1PIK3CDMTOR | |
| SCHEMBL23804768 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPIK3R1KDM4EMAPK1 | |
| SCHEMBL2674386 | 0.77 | HRH3 (0.41) | SMN1; SMN2PIK3CAPIK3R1PIK3CDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |