Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.39 |
| ▸ | CASP1 | P29466 | 17/20 | 0.39 |
| ▸ | CASP7 | P55210 | 17/20 | 0.39 |
| ▸ | USP2 | O75604 | 15/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.39 |
| ▸ | MEN1 | O00255 | 12/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.38 |
| ▸ | GLA | P06280 | 4/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239678 | 0.77 | AKT1 (0.36) | RPS6KB2 | |
| SCHEMBL2755160 | 0.77 | AKT1 (0.36) | RPS6KB2 | |
| SCHEMBL3259094 | 0.77 | AKT1 (0.34) | CYP1A2CASP1CASP7USP2HIF1A | |
| SCHEMBL239679 | 0.77 | AKT1 (0.36) | RPS6KB2 | |
| SCHEMBL2755378 | 0.72 | CYP1A2 (0.32) | CYP1A2CASP1CASP7USP2HIF1A | |
| SCHEMBL239624 | 0.72 | CYP1A2 (0.32) | CYP1A2CASP1CASP7USP2HIF1A | |
| SCHEMBL239623 | 0.72 | CYP1A2 (0.32) | CYP1A2CASP1CASP7USP2HIF1A | |
| SCHEMBL3256746 | 0.69 | RAB9A (0.36) | MEN1KMT2AHSD17B10ALDH1A1GAA | |
| SCHEMBL238677 | 0.66 | KDM4E (0.44) | CYP1A2CASP1CASP7USP2HIF1A | |
| SCHEMBL239384 | 0.65 | ALDH1A1 (0.44) | CYP1A2MEN1KMT2ACYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8614221-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2013-12-24 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | CYP1A2 4093/4885CASP1 3403/4885CASP7 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.